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Recombinant Human Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) Protein
Recombinant Human Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) Protein


生產種屬

Human

來源

Prokaryotic expression

宿主

E. coli

同義詞

IDH2; D2HGA2; ICD-M; IDH; IDHM; IDP; IDPM; mNADP-IDH

濃度

1 mg/mL

形態

Lyophilized or Liquid

純度

> 95% as determined by SDS-PAGE

序列

His354-Gln452 (P48735)

標簽

N-terminal His-tag

純化方式

Affinity purification

分子量

12 kDa

應用

Western blotting,ELISA;SDS-PAGE;Antigen;

貨號

AP50174HU

規格

100μg 500μg

價格

查詢

貨期

3-5 working days

說明書

登陸
產品概述:
Isocitrate dehydrogenase [NADP], mitochondrial is an enzyme that in humans is encoded by the IDH2 gene. Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by the IDH2 gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Somatic mosaic mutations of this gene have also been found associated to Ollier disease and Maffucci syndrome.
使用方法:
Reconstitute in PBS or others.
穩定性:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
存儲:
Store it under sterile conditions at -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -80℃.
存儲緩沖液:
Lyophilized from 50mM Tris-HCL,0.5mM EDTA,300mM NaCl,pH 9.0
注意事項:
This product is for research use only, not for diagnostic or therapeutic use.
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