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Recombinant Human Catenin beta-1 (CTNNB1) Protein
Recombinant Human Catenin beta-1 (CTNNB1) Protein


生產種屬

Human

來源

Prokaryotic expression

宿主

E. coli

同義詞

Catenin beta-1; CTNNB1; CTNNB

濃度

1 mg/mL

形態

Lyophilized or Liquid

純度

> 85% as determined by SDS-PAGE

序列

Ser 29-His 118 (P35222)

標簽

N-terminal His-tag

純化方式

Affinity purification

分子量

27 kDa

應用

Western blotting,ELISA;SDS-PAGE;Antigen;

貨號

AP50078HU

規格

100μg 500μg

價格

查詢

貨期

3-5 working days

說明書

登陸
產品概述:
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2.
使用方法:
Reconstitute in PBS or others.
穩定性:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
存儲:
Store it under sterile conditions at -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -80℃.
存儲緩沖液:
Lyophilized from 20mM PB, 300mMNaCl,pH7.7
注意事項:
This product is for research use only, not for diagnostic or therapeutic use.
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